MLS sides are set to enter the U.S. Open Cup, and several big-time matches have already been drawn for the competition’s fourth round.

A New York Derby and Cascadia clash between the Portland Timbers and Seattle Sounders headline the list of fourth round pairings drawn on Thursday. The draw determined the hosts and pairings for the competition’s fourth round, which is set for June 14.

Prior to that, though, teams from the lower divisions will participate in third-round play on May 31.

Among the more interesting fourth round matchups are a clash between Minnesota United and Sporting KC, Orlando City’s clash with either Miami FC or the Tampa Bay Rowdies and the San Jose Earthquakes’ date with the winner of the Sacramento Republic’s match against Phoenix Rising FC.

Here’s a closer look at all of the potential fourth round matchups.

Atlanta United FC (MLS) vs. Jacksonville Armada (NASL)/Charleston Battery (USL) winner

Colorado Rapids (MLS) vs. Colorado Springs Switchbacks FC (USL)/OKC Energy FC (USL) winner

D.C. United (MLS) vs. Christos FC/Chicago FC United winner

FC Cincinnati (USL)/Louisville City FC (USL) winner vs. Columbus Crew SC (MLS)

LA Galaxy vs. L.A. Wolves FC/Orange County SC (USL) winner

Michigan Bucks (PDL)/Saint Louis FC (USL) winner vs. Chicago Fire (MLS)

New England Revolution (MLS) vs. Rochester Rhinos (USL)/GPS Omens (Mass.) winner

New York Red Bulls (MLS) vs. NYCFC (MLS)

North Carolina FC (NASL)/Charlotte Independence (USL) winner vs. Houston Dynamo (MLS)

Orlando City SC (MLS) vs. Miami FC (NASL)/Tampa Bay Rowdies (USL) winner

Philadelphia Union (MLS) vs. Reading United AC (PDL)/Harrisburg City Islanders (USL) winner

Reno 1868 FC (USL)/Sacramento Republic FC (USL) winner vs. Real Salt Lake (MLS)

San Jose Earthquakes (MLS) vs. San Francisco Deltas (NASL)/Phoenix Rising FC (USL) winner

Seattle Sounders FC (MLS) vs. Portland Timbers (MLS)

Sporting Kansas City (MLS) vs. Minnesota United FC (MLS)

San Antonio FC (USL) vs. FC Dallas (MLS) or FC Dallas (MLS) vs. Tulsa Roughnecks FC (USL)