A trio of second half goals saw FC Dallas come from behind to topple the rival Houston Dynamo.
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Ignacio Piatti scored a late winner to lead the 10-man Montreal Impact to a statement win over Toronto FC.
Both Wil Trapp and David Bingham exited with injuries, but Ethan Finlay and Justin Meram combined to lead the Columbus Crew to a win over the San Jose Earthquakes.
Patrick Mullins was of several standouts on Saturday night as D.C. United thumped the Chicago Fire at RFK Stadium.
Toronto FC takes on Montreal while the Houston Dynamo face FC Dallas on a busy Saturday night in MLS.
Clint Dempsey is undergoing medical evaluations for an irregular heartbeat and will miss the Seattle Sounders’ clash with the Portland Timbers this weekend.
The Bundesliga returns to action over the weekend, while the English Premier League provides several interesting matchups including young American stars.