The Seattle Sounders will travel to Mexico to face Club America, while Real Salt Lake hosts Tigres UANL at Rio Tinto Stadium later on Wednesday.
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D.C. United will host Mexican club Queretaro in its second leg, while the LA Galaxy travel to Mexico to play Santos Laguna at Estadio Corona.
The LA Galaxy unveiled their new-look squad on Wednesday night, but failed to find a goal in shutting out Santos Laguna in a 0-0 draw in CONCACAF Champions League quarterfinal action.
A Nick Rimando penalty-kick stop was not enough to lead Real Salt Lake to victory vs. Tigres UANL in the first leg of their CONCACAF Champions League quarterfinals series.
Manchester City and Atletico Madrid enter Wednesday’s UEFA Champions League action as favorites, while Real Salt Lake and the LA Galaxy take on Mexican foes in the CONCACAF Champions League.
Querétaro defeated D.C. United, 2-0, in the first leg of their quarterfinals series in the CONCACAF Champions League.