In dramatic fashion, Orlando City SC scored two goals in second-half stoppage time to tie Real Salt Lake, 2-2, in front more than 60,000 people at the Citrus Bowl.
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Tigres UANL tied Real Salt Lake, 1-1, securing advancement to the CONCACAF Champions League semifinals with a 3-1 aggregate win across two legs.
The Seattle Sounders will travel to Mexico to face Club America, while Real Salt Lake hosts Tigres UANL at Rio Tinto Stadium later on Wednesday.
The MLS preseason came to an end on Saturday, and it ended in spectacular fashion as defender Seb Hines scored four goals against Brazilian competition.