Leicester City plays Manchester United with a chance to clinch the 2015-16 English Premier League title and more.
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The Spanish La Liga title race continues on Saturday, as Barcelona, Atletico Madrid and Real Madrid all kick off.
In a pair of Europa League clashes, Liverpool takes on Villarreal while reigning champions Sevilla face off with Shakhtar Donetsk.
Manchester City and Real Madrid begin the UEFA Champions League semifinals, while the Copa Libertadores round of 16 begins Tuesday evening.
Two matches in two different nations have important title implications as both the English Premier League and Italian Serie A seasons approach their ends.
Leicester City hosts Swansea City at King Power Stadium to headline English Premier League action, while Crystal Palace and Watford face off in the English FA Cup.
Everton and Manchester United kick off in the English FA Cup semifinals, while Hertha Berlin-Bayern Munich, Atlético Madrid-Málaga and Club América-Toluca headline action.