While an intense showdown between Lazio and AS Roma headlines Serie A action, Leicester City-Southampton and Manchester United-Everton will have most people’s attention.
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All eyes will be on Saturday’s El Clasico between Barcelona and Real Madrid, while Tottenham hosts Liverpool in English Premier League action.
CONCACAF World Cup qualifying returns on Friday night, while an evening clash between Uruguay and Brazil headlines the international action.
The Manchester derby takes center stage, while Real Madrid-Sevilla, Paris Saint-Germain-AS Monaco and FC Augsburg-Borussia Dortmund are all games to keep an eye on.
Everton-Arsenal, AS Roma-Inter Milan and Club América-Club León headline a jam-packed Saturday full of intriguing contests.
While an important English Championship takes place at Riverside Stadium, Schalke 04 and Borussia Monchengladbach will meet in a top-of-the-table clash.
Tottenham-Borussia Dortmund and Manchester United-Liverpool headline UEFA Europa League action this Thursday.