In a pair of Europa League clashes, Liverpool takes on Villarreal while reigning champions Sevilla face off with Shakhtar Donetsk.
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Manchester City and Real Madrid begin the UEFA Champions League semifinals, while the Copa Libertadores round of 16 begins Tuesday evening.
Two matches in two different nations have important title implications as both the English Premier League and Italian Serie A seasons approach their ends.
Leicester City hosts Swansea City at King Power Stadium to headline English Premier League action, while Crystal Palace and Watford face off in the English FA Cup.
Everton and Manchester United kick off in the English FA Cup semifinals, while Hertha Berlin-Bayern Munich, Atlético Madrid-Málaga and Club América-Toluca headline action.
Arsenal hosts West Bromwich Albion at the Emirates Stadium to headline action across the world on Thursday.
Paris Saint-Germain and Bayern Munich take the field for cup action, while Manchester City takes on Newcastle to headline Tuesday’s league schedule.